Turkey Tetrazzini Casserole (Leftover Thanksgiving) + Video
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This leftover turkey casserole has pasta and vegetables in a creamy sauce with a crispy cracker topping. Use your Thanksgiving leftovers to make it! Everyone will love this easy leftover casserole for the perfect quick next day meal!
I’m all about the flavors of this delicious casserole. It takes just minutes of prep, and it’s a great way to use up leftovers from Thanksgiving dinner.
Having an easy way to feed the whole family with this creamy turkey casserole scores high on my card!
A lot of casserole recipes can be long and complicated, but not this one! It’s loaded with your favorite holiday leftovers and the best way to reduce waste.
Good recipes like this are really a meal in themselves, but I still like to pair it with a simple green salad to round out the flavors.
I usually have a bit of turkey leftovers, so it’s perfect for this low-carb turkey casserole. And the best part?
It gives us a good reason to enjoy the best foods from the holidays all over again! Just pair it with some leftover cranberry sauce or leftover gravy – and you’re set!
Make this easy recipe as the perfect way to use up those leftovers! You could also actually tweak the recipe a bit to make it any time of year.
Instead of using leftover Thanksgiving turkey, you can use leftover ham from Christmas or even leftover chicken from a different meal. This great recipe gives options!
Leftover Turkey Casserole
I don’t like to let food go to waste, so I typically use Thanksgiving leftovers to make simple dinners for the week.
Making this easy turkey tetrazzini recipe is the perfect use for any leftover turkey in your fridge. It’s a fantastic comfort food, and much better than making endless sandwiches!
Slow Cooker Turkey Chili is another easy leftover turkey recipe. Just add everything at once and let your crockpot do the work.
Or, make my Chicken Enchilada Casserole with turkey instead. It only has 5 ingredients and is ready in about 30 minutes.
Recipe Video
Be sure to watch the video! Look for it in the recipe card, at the bottom of this post.
Watch the video to see the process of making the casserole from start to finish! Look for it in the recipe card at the bottom of this post.
Ingredient Notes and Substitutions
- Turkey – Feel free to use cooked chicken instead! Cook up some chicken breasts or grab a rotisserie chicken from the store.
- Mushrooms – I like the extra savory flavor of baby Bella mushrooms (sometimes labeled as “cremini”), but regular white button mushrooms will work just fine.
- Frozen Peas – These add some color and another serving of vegetables, but you can certainly substitute another small frozen veggie (like carrots), or leave them out if you prefer.
- Shredded Cheese – Get a bolder flavor and a smoother sauce by shredding a fresh block of cheese.
Pre-bagged shreds have an added preservative to prevent clumping that often gives the cheese a waxy texture. I like using a little bit of cheddar cheese in mind. - Butter Crackers – Ritz crackers are my favorite, but Panko bread crumbs or crushed potato chips would make a great substitute for this easy turkey casserole!
How to Make Easy Turkey Tetrazzini
This casserole recipe couldn’t be much simpler to make!
- Cook the spaghetti. Only cook the noodles to al dente. This means they should have a slight chewiness or “bite” to them.
- Chop the meat. While the spaghetti is cooking, you can chop up or shred your leftover turkey and set it aside to add to the sauce.
- Make the sauce. Start by sautéing the mushrooms in butter or oil. Then, you’ll add some flour to make a roux (a combination of fat and flour) to thicken the sauce.
PRO TIP: Whisk in the liquids SLOWLY to avoid clumps of flour. - Combine sauce, turkey, and spaghetti in a casserole dish.
- Make the buttery cracker topping. Sprinkle it over the leftover turkey casserole and bake until bubbly and golden brown.
Serving Suggestions
Because this meal is hearty and filling, it works as a complete meal all by itself.
If you’d still like to add a side dish, keep it simple. Soft breadsticks or pumpkin dinner rolls along with a green salad would be perfect.
Leftover Turkey Casserole FAQ
Sure! Just follow the recipe up until baking, but leave off the cracker topping. Wrap tightly with plastic wrap, and refrigerate overnight.
When you’re ready to bake, remove the plastic, add the topping, and bake as directed. You may need to add a few extra minutes since it’s going into the oven cold.
While I haven’t tried any others myself, I’m sure Pepper Jack or even mozzarella would taste great.
Yes! Leftover turkey casserole freezes beautifully, so it is a great option for make-ahead meals!
Allow the dinner to cool completely in the dish, then cover tightly with plastic wrap and foil and freeze for up to 6 months.
When you’re ready to reheat it, first thaw in the refrigerator overnight. Then, bake until it’s bubbly and warmed through.
If you have a large enough sauté pan, you could double the recipe and split it between two baking dishes. Have one for dinner and freeze the other!
Enjoy!
With love, from our simple kitchen to yours.
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Other Easy Dinner Casseroles
Turkey Tetrazzini Casserole (Leftover Thanksgiving) + Video
Equipment
- large pot for cooking spaghetti
Ingredients
- 1 pound spaghetti, cooked to al dente, drained, rinsed, and returned to the pot. See Notes
- 10 tablespoons unsalted butter, divided
- 1/2 cup diced onion
- 4 cloves garlic, minced
- 8 ounces baby bella mushrooms, sliced
- 1 teaspoon dried thyme
- 1 teaspoon kosher salt
- 1/2 teaspoon black pepper
- 1/2 cup all-purpose flour
- 2 1/2 cups chicken stock
- 2 1/2 cups whole milk, or 2% milk
- 8 ounces cream cheese, softened and cut into 8 pieces
- 16 ounces shredded cheddar cheese, divided
- 4 cups diced or shredded cooked turkey
- 1 1/2 cups frozen peas, unthawed
- 1 cup crushed butter crackers, such as Ritz
- 1/4 cup freshly grated parmesan cheese
- 3 tablespoons chopped flat leaf parsley, optional, for garnish
Instructions
- Preheat the oven to 350°F. Grease a 9×13 inch baking dish with non-stick cooking spray or olive oil spray, and set dish aside.
- To a large sauté pan over medium-low heat, add 8 tablespoons of butter; allow it to melt.Add the onion and sauté, stirring occasionally, until onions are soft and translucent, about 5 minutes. Add the garlic and cook until fragrant, about 30 seconds.Add the mushrooms, thyme, salt, and pepper. Cook, stirring occasionally, until the mushrooms are softened, about 5 minutes.
- Add the flour to the pan and stir it in to coat the veggies. Cook for 2 minutes, stirring once or twice. Slowly and gradually, whisk in the stock, about 1/4 cup at a time, then add all of the milk. Stir to combine. Bring contents to a light boil over high heat, then immediately reduce heat to medium-low and simmer until thickened. Add the cream cheese and stir occasionally until melted. Add half of the cheddar cheese. Continue to cook, stirring occasionally until melted. Remove pan from the heat and stir in the cooked turkey and peas.
- Add sauce to the pot of cooked spaghetti and stir thoroughly to combine. Pour into the prepared baking dish, top with the remaining cheddar cheese, and set aside.
- Melt the remaining 2 tablespoons of butter in a medium-sized bowl in the microwave, or use a small pan on the stovetop. Add crushed crackers and shredded parmesan cheese to melted butter; stir to combine. Sprinkle cracker mixture evenly over top of casserole.
- Bake for 25-30 minutes, or until the top is golden brown. Garnish with chopped parsley if desired. Serve while warm.
Video
Donna’s Notes
- Pasta cooked to al dente means it should have a slight bite to it, but not undercooked or crunchy. (Pasta will finish cooking as the casserole bakes in the oven). After draining and rinsing spaghetti, return noodles to the cooking pot. Sauce will be combined with them later.
- May substitute spaghetti with any long thin pasta, such as spaghettini, angel hair, or fettuccine.
Nutrition
All nutritional information is based on third party calculations and is only an estimate. Each recipe’s nutritional value will vary depending on the ingredients used, measuring methods, and portion sizes.
Originally published September 2021, updated and republished October 2024
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I have not made this so can’t rate it but I do have a question. The list of ingredients includes “10 tablespoons unsalted butter, divided”; however, in the instructions, I can only account for 8 Tbsp butter – 6 to cook onion and 2 for topping. Where are the other 2 Tbsp? Added with mushrooms? garlic? flour?
Hi Bev,
Thanks for catching this typo! 8 tablespoons butter should be added to the pan, not 6. The recipe card has been updated to reflect this.
I like using turkey as my “healthy” meat for cooking and was excited to try this. It is so delicious. It truly is a comfort food style dish. Very filling, delicious, and satisfying.